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Lara B. Genital herpes in persons with HIV type 1 HIV-1 infection is associated with more-severe and chronic lesions, as well as increased rates of asymptomatic genital shedding of HSV Nucleoside analogues acyclovir, valacyclovir, and famciclovir decrease the frequency and severity of HSV-2 recurrences and asymptomatic HSV-2 reactivation and are effective, safe, well-tolerated drugs in patients with HIV-1 infection.
Given these benefits, HIV-1—infected persons should be routinely tested for HSV-2 infection using type-specific serologic tests. Herpes simplex virus type 2 HSV-2 is a highly prevalent sexually transmitted infection [ 1—3 ]. With the advent of better diagnostic assays e. HSV-2 infection is also one of the most common infections among HIV-infected persons, partly because of the shared route of sexual transmission [ 3 , 9—13 ]. Anogenital herpes was one of the first opportunistic infections described in persons with AIDS, and persistent herpetic ulceration is an AIDS-defining illness [ 20 , 21 ].
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